Pachymic acid
CAS No. 29070-92-6
Pachymic acid ( 3-O-Acetyltumulosic acid )
Catalog No. M22084 CAS No. 29070-92-6
Pachymic acid is a natural product, and inhibits Akt and ERK signaling pathways.Pachymic acid(PA) exhibited anti-tumor effects in vitro accompanied by induction of G2/M phase arrest and apoptosis in NCI-H23 and NCI-H460 lung cancer cells.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 159 | In Stock |
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10MG | 249 | In Stock |
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25MG | 474 | In Stock |
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50MG | 686 | In Stock |
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100MG | 963 | In Stock |
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200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NamePachymic acid
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NoteResearch use only, not for human use.
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Brief DescriptionPachymic acid is a natural product, and inhibits Akt and ERK signaling pathways.Pachymic acid(PA) exhibited anti-tumor effects in vitro accompanied by induction of G2/M phase arrest and apoptosis in NCI-H23 and NCI-H460 lung cancer cells.?
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DescriptionPachymic acid is a natural product, and inhibits Akt and ERK signaling pathways.Pachymic acid(PA) exhibited anti-tumor effects in vitro accompanied by induction of G2/M phase arrest and apoptosis in NCI-H23 and NCI-H460 lung cancer cells.?Mechanistically, our data showed that PA induced reactive oxygen species (ROS) production, resulting in the activation of both c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in lung cancer cells.?Moreover, blockage of ROS production reversed PA-induced JNK and ER stress activation.?Finally, PA inhibited the growth of NCI-H23 xenograft tumors without causing any host toxicity, and inhibited cell proliferation and induction of apoptosis of tumor cells in tumor xenograft tissues.PA significantly reduced cell growth in a dose- and time-dependent fashion. Meanwhile, cell cycle arrest at G0 phase was induced by PA. PA also significantly inhibited cancer cell migration, invasion in a dose-dependent manner. Interestingly,demonstrated that cancer cell adhesion ability was suppressed dose-dependently, which may contribute to the inhibition of cell invasion. Finally, showed that PA inhibited AKT and ERK signaling pathways. And oncoproteins, such as PCNA, ICAM-1 and RhoA which are involved intumorigenesis, were also downregulated by PA.
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Synonyms3-O-Acetyltumulosic acid
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetAkt
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RecptorAkt;ERK
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Research Area——
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Indication——
Chemical Information
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CAS Number29070-92-6
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Formula Weight528.77
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Molecular FormulaC33H52O5
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Purity>98% (HPLC)
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SolubilityDMSO:7 mg/mL (13.24 mM; Need ultrasonic)
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SMILES[H][C@]1([C@@H](CCC(=C)C(C)C)C(O)=O)[C@H](O)C[C@@]2(C)C3=C(CC[C@]12C)[C@@]1(C)CC[C@H](OC(C)=O)C(C)(C)[C@]1([H])CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ma J, et al. Pachymic acid induces apoptosis via activating ROS-dependent JNK and ER stress pathways in lung cancer cells. Cancer Cell Int. 2015 Aug 5;15:78.
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